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Since tetracyclines can cause negative effects on bone, the use of tetracyclines in nursing mothers is of concern.
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Phenytoin, carbamazepine, and barbiturates may enhance the metabolism (destruction) of doxycycline thus making it less effective.
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It is recommended that doxycycline not be taken at the same time as aluminum, magnesium, or calcium based antacids, such as Maalox, Mylanta, Tums, or Rolaids because, like food, these medications bind doxycycline in the intestine and prevent its absorption.